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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM9273
Substrate
n/a
Meas. Tech.
ChEMBL_2302128
IC50
4.2±n/a nM
Citation
 Subbaiah, MAM; Meanwell, NA; Kadow, JF Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties. Eur J Med Chem 139:865-883 (2017) [PubMed] 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM9273
Synonyms:
(3S)-oxolan-3-yl N-[(2S,3R)-3-hydroxy-4-[(4-methoxybenzene)(2-methylpropyl)sulfonamido]-1-phenylbutan-2-yl]carbamate | (hydroxyethylamino)sulfonamide deriv. 12
Type:
Small organic molecule
Emp. Form.:
C26H36N2O7S
Mol. Mass.:
520.638
SMILES:
[H][C@@]1(CCOC1)OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN(CC(C)C)S(=O)(=O)c1ccc(OC)cc1 |r|
Structure:
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