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Target
Histamine H3 receptor
Ligand
BDBM50615410
Substrate
n/a
Meas. Tech.
ChEMBL_2302321
Ki
1.2±n/a nM
Citation
 Ledneczki, I; Tapolcsányi, P; Gábor, E; Éles, J; Greiner, I; Schmidt, É; Némethy, Z; Kedves, RS; Balázs, O; Román, V; Lévay, G; Mahó, S Discovery of novel steroidal histamine H Bioorg Med Chem Lett 27:4525-4530 (2017) [PubMed] 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50615410
Synonyms:
CHEMBL5279080
Type:
Small organic molecule
Emp. Form.:
C30H46N2O
Mol. Mass.:
450.699
SMILES:
[H][C@@]12CC[C@H](N3CCCC3)[C@@]1(C)CC[C@]1([H])c3ccc(OCCCN4CCCC4)cc3C[C@@H](C)[C@@]21[H] |r|
Structure:
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