Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50211627
Substrate
n/a
Meas. Tech.
ChEMBL_455617 (CHEMBL886398)
Ki
2.5±n/a nM
Citation
 Lavey, BJ; Kozlowski, JA; Shankar, BB; Spitler, JM; Zhou, G; Yang, DY; Shu, Y; Wong, MK; Wong, SC; Shih, NY; Wu, J; McCombie, SW; Rizvi, R; Wolin, RL; Lunn, CA Optimization of triaryl bis-sulfones as cannabinoid-2 receptor ligands. Bioorg Med Chem Lett 17:3760-4 (2007) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50211627
Synonyms:
(S)-trifluoro-N-(1-(4-(2-(2-fluorophenylsulfonyl)-4-(2-methoxyethoxy)phenylsulfonyl)phenyl)ethyl)methanesulfonamide | CHEMBL396169
Type:
Small organic molecule
Emp. Form.:
C24H23F4NO8S3
Mol. Mass.:
625.63
SMILES:
COCCOc1ccc(c(c1)S(=O)(=O)c1ccccc1F)S(=O)(=O)c1ccc(cc1)[C@H](C)NS(=O)(=O)C(F)(F)F
Structure:
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