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Target
Mitogen-activated protein kinase 9
Ligand
BDBM50215054
Substrate
n/a
Meas. Tech.
ChEMBL_456441 (CHEMBL907530)
IC50
2±n/a nM
Citation
Moss, N; Breitfelder, S; Betageri, R; Cirillo, PF; Fadra, T; Hickey, ER; Kirrane, T; Kroe, RR; Madwed, J; Nelson, RM; Pargellis, CA; Qian, KC; Regan, J; Swinamer, A; Torcellini, C New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site. Bioorg Med Chem Lett 17:4242-7 (2007) [PubMed] Article
More Info.:
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Human
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
Inhibitor
Name:
BDBM50215054
Synonyms:
1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(6-(morpholinomethyl)pyridin-3-yl)naphthalen-1-yl)urea | CHEMBL381743
Type:
Small organic molecule
Emp. Form.:
C35H38N6O2
Mol. Mass.:
574.7152
SMILES:
Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(-c2ccc(CN3CCOCC3)nc2)c2ccccc12)C(C)(C)C