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Target
B1 bradykinin receptor
Ligand
BDBM50222678
Substrate
n/a
Meas. Tech.
ChEMBL_446484 (CHEMBL895596)
IC50
1.8±n/a nM
Citation
Dressen, D; Garofalo, AW; Hawkinson, J; Hom, D; Jagodzinski, J; Marugg, JL; Neitzel, ML; Pleiss, MA; Szoke, B; Tung, JS; Wone, DW; Wu, J; Zhang, H Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists. J Med Chem 50:5161-7 (2007) [PubMed] Article
More Info.:
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Human
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Inhibitor
Name:
BDBM50222678
Synonyms:
4-bromo-5-(2-chlorobenzamido)-N-(2-(1'-methyl-1,4'-bipiperidin-4-yl)ethyl)-1Hpyrazole-3-carboxamide | CHEMBL397248
Type:
Small organic molecule
Emp. Form.:
C24H32BrClN6O2
Mol. Mass.:
551.907
SMILES:
CN1CCC(CC1)N1CCC(CCNC(=O)c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br)CC1