Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50248956
Substrate
n/a
Meas. Tech.
ChEMBL_541388 (CHEMBL1023943)
Ki
30±n/a nM
Citation
 Zampieri, D; Grazia Mamolo, M; Laurini, E; Zanette, C; Florio, C; Collina, S; Rossi, D; Azzolina, O; Vio, L Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site. Eur J Med Chem 44:124-30 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
Rat
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50248956
Synonyms:
3-((1-(2,4-dimethylbenzyl)piperidin-4-yl)methyl)benzo[d]oxazol-2(3H)-one | 3-[[1-(2,4-Dimethylbenzyl)piperidin-4-yl]methyl]benzo[d]oxazol-2(3H)-one | CHEMBL514488
Type:
Small organic molecule
Emp. Form.:
C22H26N2O2
Mol. Mass.:
350.454
SMILES:
Cc1ccc(CN2CCC(Cn3c4ccccc4oc3=O)CC2)c(C)c1
Structure:
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