Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM50251748
Substrate
n/a
Meas. Tech.
ChEMBL_488511 (CHEMBL991044)
IC50
290±n/a nM
Citation
 Gong, Y; Barbay, JK; Buntinx, M; Li, J; Wauwe, JV; Claes, C; Lommen, GV; Hornby, PJ; He, W Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists. Bioorg Med Chem Lett 18:3852-5 (2008) [PubMed]  Article 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Human
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM50251748
Synonyms:
2-(2,6-diethylphenyl)-4-methoxy-N-(2-methyl-5-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroquinolin-5-amine | CHEMBL480156
Type:
Small organic molecule
Emp. Form.:
C28H31F3N2O
Mol. Mass.:
468.5537
SMILES:
CCc1cccc(CC)c1-c1cc(OC)c2C(CCCc2n1)Nc1cc(ccc1C)C(F)(F)F
Structure:
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