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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50262002
Substrate
n/a
Meas. Tech.
ChEMBL_509554 (CHEMBL997868)
Ki
24±n/a nM
Citation
 Sato, N; Jitsuoka, M; Shibata, T; Hirohashi, T; Nonoshita, K; Moriya, M; Haga, Y; Sakuraba, A; Ando, M; Ohe, T; Iwaasa, H; Gomori, A; Ishihara, A; Kanatani, A; Fukami, T (9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist. J Med Chem 51:4765-70 (2008) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50262002
Synonyms:
9'-(2-Hydroxy-4-oxospiro[5.5]undec-3-yl)-4',9'-dihydrospiro[cyclohexane-1,3'-xanthen]-1'(2'H)-one | CHEMBL466756
Type:
Small organic molecule
Emp. Form.:
C29H34O4
Mol. Mass.:
446.5779
SMILES:
O=C1CC2(CCCCC2)CC(=O)C1C1C2=C(CC3(CCCCC3)CC2=O)Oc2ccccc12 |t:16|
Structure:
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