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Target
Vasopressin V1a receptor
Ligand
BDBM50262327
Substrate
n/a
Meas. Tech.
ChEMBL_513958 (CHEMBL974599)
Ki
4300±n/a nM
Citation
 Brown, A; Brown, L; Ellis, D; Puhalo, N; Smith, CR; Wallace, O; Watson, L Design and optimization of potent, selective antagonists of Oxytocin. Bioorg Med Chem Lett 18:4278-81 (2008) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50262327
Synonyms:
4-(5-(5-(methoxymethyl)-4-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl)pyrazin-2-yl)-3-methylbenzonitrile | CHEMBL469005
Type:
Small organic molecule
Emp. Form.:
C22H19N7O2
Mol. Mass.:
413.432
SMILES:
COCc1nnc(-c2cnc(cn2)-c2ccc(cc2C)C#N)n1-c1ccc(OC)nc1
Structure:
Search PDB for entries with ligand similarity: