Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50272668
Substrate
n/a
Meas. Tech.
ChEMBL_510057 (CHEMBL995200)
Ki
27±n/a nM
Citation
 Regan, CFGuo, ZChen, YHuang, CQChen, MJiang, WRueter, JKCoon, TChen, CSaunders, JBrown, MSBetz, SFStruthers, RSYang, CWen, JMadan, AZhu, YF Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties. Bioorg Med Chem Lett 18:4503-7 (2008) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Human
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50272668
Synonyms:
(R)-2-(2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)ethylamino)acetic acid | CHEMBL502967
Type:
Small organic molecule
Emp. Form.:
C32H31F5N4O5
Mol. Mass.:
646.6044
SMILES:
CN[C@@H](Cn1c(=O)c(c(C)n(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1cccc(OCCNCC(O)=O)c1F)c1ccccc1 |r,wD:2.1,(12.22,-28.79,;13.55,-28.02,;13.55,-26.48,;14.88,-25.7,;16.22,-26.47,;17.55,-25.69,;17.55,-24.15,;18.87,-26.47,;18.87,-28.01,;20.21,-28.78,;17.55,-28.77,;17.55,-30.31,;16.76,-31.64,;17.59,-32.92,;19.13,-32.84,;16.9,-34.29,;15.35,-34.37,;14.52,-33.08,;15.22,-31.71,;14.39,-30.41,;13.57,-29.11,;13.09,-31.24,;15.69,-29.59,;16.22,-28.01,;14.88,-28.78,;20.2,-25.71,;21.54,-26.48,;22.87,-25.72,;22.88,-24.18,;21.54,-23.4,;21.53,-21.86,;22.87,-21.09,;22.87,-19.55,;24.2,-18.78,;24.2,-17.24,;25.53,-16.47,;26.87,-17.24,;25.54,-14.93,;20.21,-24.17,;18.87,-23.4,;12.21,-25.71,;12.22,-24.17,;10.88,-23.41,;9.55,-24.18,;9.56,-25.73,;10.89,-26.49,)|
Structure:
Search PDB for entries with ligand similarity: