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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50252711
Substrate
n/a
Meas. Tech.
ChEMBL_538852 (CHEMBL1033095)
IC50
<20±n/a nM
Citation
 Yang, ZQ; Barrow, JC; Shipe, WD; Schlegel, KA; Shu, Y; Yang, FV; Lindsley, CW; Rittle, KE; Bock, MG; Hartman, GD; Uebele, VN; Nuss, CE; Fox, SV; Kraus, RL; Doran, SM; Connolly, TM; Tang, C; Ballard, JE; Kuo, Y; Adarayan, ED; Prueksaritanont, T; Zrada, MM; Marino, MJ; Graufelds, VK; DiLella, AG; Reynolds, IJ; Vargas, HM; Bunting, PB; Woltmann, RF; Magee, MM; Koblan, KS; Renger, JJ Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels. J Med Chem 51:6471-7 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50252711
Synonyms:
3,5-Dichloro-N-{[(3S,4R)-1-(3,3-dimethylbutyl)-3-fluoropiperidin-4-yl]methyl}benzamide | CHEMBL493677
Type:
Small organic molecule
Emp. Form.:
C19H27Cl2FN2O
Mol. Mass.:
389.335
SMILES:
CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 |r|
Structure:
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