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Target
Bombesin receptor subtype-3
Ligand
BDBM50275843
Substrate
n/a
Meas. Tech.
ChEMBL_496868 (CHEMBL998537)
EC50
240±n/a nM
Citation
 Carlton, DL; Collin-Smith, LJ; Daniels, AJ; Deaton, DN; Goetz, AS; Laudeman, CP; Littleton, TR; Musso, DL; Morgan, RJ; Szewczyk, JR; Zhang, C Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole lead. Bioorg Med Chem Lett 18:5451-5 (2008) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Human
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50275843
Synonyms:
2-((6-chlorobenzo[d][1,3]dioxol-5-yloxy)methyl)-6-(trifluoromethyl)-1H-benzo[d]imidazole | CHEMBL513374
Type:
Small organic molecule
Emp. Form.:
C16H10ClF3N2O3
Mol. Mass.:
370.71
SMILES:
FC(F)(F)c1ccc2nc(COc3cc4OCOc4cc3Cl)[nH]c2c1
Structure:
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