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Target
Mu-type opioid receptor
Ligand
BDBM50246027
Substrate
n/a
Meas. Tech.
ChEMBL_559150 (CHEMBL1012095)
Ki
752±n/a nM
Citation
 Yang, SW; Ho, G; Tulshian, D; Greenlee, WJ; Fernandez, X; McLeod, RL; Eckel, S; Anthes, J Structure-activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough. Bioorg Med Chem Lett 18:6340-3 (2008) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50246027
Synonyms:
(rel)-N-((8-(bis(2-chlorophenyl)methyl)-3-(5-bromopyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methyl)acetamide | CHEMBL473508
Type:
Small organic molecule
Emp. Form.:
C28H28BrCl2N3O
Mol. Mass.:
573.351
SMILES:
CC(=O)NCC1(C[C@@H]2CC[C@@H](C1)N2C(c1ccccc1Cl)c1ccccc1Cl)c1ccc(Br)cn1 |r,TLB:4:5:12:8.9|
Structure:
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