Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 4
Ligand
BDBM50243945
Substrate
n/a
Meas. Tech.
ChEMBL_558792 (CHEMBL1020786)
IC50
39±n/a nM
Citation
Yokoyama, K; Ishikawa, N; Igarashi, S; Kawano, N; Masuda, N; Hamaguchi, W; Yamasaki, S; Koganemaru, Y; Hattori, K; Miyazaki, T; Ogino, S; Matsumoto, Y; Takeuchi, M; Ohta, M Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem 17:64-73 (2008) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | CC-CKR-4 | CCR-4 | CCR4_MOUSE | CD_antigen=CD194 | Ccr4 | Cmkbr4
Type:
PROTEIN
Mol. Mass.:
41410.76
Organism:
Mouse
Description:
ChEMBL_512157
Residue:
360
Sequence:
MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYTEHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL
Inhibitor
Name:
BDBM50243945
Synonyms:
2-(1,4'-Bipiperidine-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine | 2-(1,4'-bipiperidin-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine | CHEMBL508207 | N-cycloheptyl-6,7-dimethoxy-2-(4-(piperidin-1-yl)piperidin-1-yl)quinazolin-4-amine
Type:
Small organic molecule
Emp. Form.:
C27H41N5O2
Mol. Mass.:
467.6467
SMILES:
COc1cc2nc(nc(NC3CCCCCC3)c2cc1OC)N1CCC(CC1)N1CCCCC1