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Target
Prostaglandin G/H synthase 2
Ligand
BDBM50279625
Substrate
n/a
Meas. Tech.
ChEMBL_545260 (CHEMBL1020706)
IC50
2000±n/a nM
Citation
 Dündar, Y; Unlü, S; Banoqlu, E; Entrena, A; Costantino, G; Nuñez, MT; Ledo, F; Sahin, MF; Noyanalpan, N Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors. Eur J Med Chem 44:1830-7 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
COX2 | Cyclooxygenase-1 (COX-1) | Cyclooxygenase-2 (COX-2) | PGH2_SHEEP | PTGS2 | Prostaglandin G/H synthase (Cyclooxygenase-2) | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68976.98
Organism:
Sheep
Description:
n/a
Residue:
603
Sequence:
MLARALLLCAAVVCGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPDTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHYSYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTDIERGPAFTKGKNHGVDLSHVYGESLERQHNRRLFKDGKMKYQMINGEMYPPTVKDTQVEMIYPPHIPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGVTQFVESFTRQIAGRVAGRRNLPAAVEKVSKASLDQSREMKYQSFNEYRKRFLLKPYESFEELTGEKEMAAELEALYGDIDAMELYPALLVEKPAPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEVGFKIINTASIQSLICSNVKGCPFTSFSVQDAHLTKTVTINASSSHSGLDDINPTVLLKERSTEL
  
Inhibitor
Name:
BDBM50279625
Synonyms:
4-(4-Phenyl-3-methyl-2-oxo-3H-1,3-oxazol-5-yl)benzensulfonamide | CHEMBL484814
Type:
Small organic molecule
Emp. Form.:
C16H14N2O4S
Mol. Mass.:
330.358
SMILES:
Cn1c(c(oc1=O)-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: