Reaction Details Report a problem with these data
Target
Beta-3 adrenergic receptor
Ligand
BDBM50243112
Substrate
n/a
Meas. Tech.
ChEMBL_497791 (CHEMBL1007087)
EC50
0.260000±n/a nM
Citation
Hattori, K; Toda, S; Imanishi, M; Itou, S; Nakajima, Y; Washizuka, K; Araki, T; Hamashima, H; Tomishima, Y; Sakurai, M; Matsui, S; Imamura, E; Ueshima, K; Yamamoto, T; Yamamoto, N; Ishikawa, H; Nakano, K; Unami, N; Hamada, K; Matsumura, Y; Takamura, F Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5. J Med Chem 52:3063-72 (2009) [PubMed] Article
More Info.:
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Inhibitor
Name:
BDBM50243112
Synonyms:
(R)-3-(cyclohexyloxy)-4'-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)biphenyl-4-carboxylic acid | 3-(Cyclohexyloxy)-4-(2-{[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino}-ethyl)-4-biphenylcarboxylic acid | CHEMBL488224
Type:
Small organic molecule
Emp. Form.:
C28H32N2O4
Mol. Mass.:
460.5647
SMILES:
O[C@@H](CNCCc1ccc(cc1)-c1ccc(C(O)=O)c(OC2CCCCC2)c1)c1cccnc1 |r|