Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50249803
Substrate
n/a
Meas. Tech.
ChEMBL_498773 (CHEMBL1021965)
Ki
2.5±n/a nM
Citation
Sato, N; Ando, M; Ishikawa, S; Jitsuoka, M; Nagai, K; Takahashi, H; Sakuraba, A; Tsuge, H; Kitazawa, H; Iwaasa, H; Mashiko, S; Gomori, A; Moriya, R; Fujino, N; Ohe, T; Ishihara, A; Kanatani, A; Fukami, T Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect. J Med Chem 52:3385-96 (2009) [PubMed] Article
More Info.:
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Human
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
Inhibitor
Name:
BDBM50249803
Synonyms:
2-Fluoro-5-{(4S,5S)-4-(4-fluorophenyl)-5-methyl-2-[3-(methylsulfonyl) phenyl]-4,5-dihydro-1H-imidazol-4-yl}pyridine | CHEMBL491894
Type:
Small organic molecule
Emp. Form.:
C22H19F2N3O2S
Mol. Mass.:
427.467
SMILES:
C[C@@H]1NC(=N[C@@]1(c1ccc(F)cc1)c1ccc(F)nc1)c1cccc(c1)S(C)(=O)=O |r,c:3|