Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50242184
Substrate
n/a
Meas. Tech.
ChEMBL_156194 (CHEMBL767138)
IC50
15±n/a nM
Citation
 Glaser, KB; Sung, ML; Lock, YW; Bauer, J; Kubrak, D; Kreft, A Analogs of the marine natural product scalaradial lacking the α,β-unsaturated aldehyde: effects on human synovial fluid phospholipase A2 and macrophage lipid mediator production Bioorg Med Chem Lett 4:1873-1878 (1994)    Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50242184
Synonyms:
Scalaradial
Type:
Small organic molecule
Emp. Form.:
C27H40O4
Mol. Mass.:
428.6041
SMILES:
[H][C@@]12CC[C@@]3(C)[C@]4([H])CC=C(C=O)[C@H](C=O)[C@@]4(C)[C@H](C[C@]3([H])[C@@]1(C)CCCC2(C)C)OC(C)=O |r,t:9|
Structure:
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