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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50285205
Substrate
n/a
Meas. Tech.
ChEBML_51690
IC50
>50000±n/a nM
Citation
 Leblanc, Y; Gauthier, J; Ethier, D; Guay, J; Mancini, J; Riendeau, D; Tagari, P; Vickers, P; Wong, E; Prasit, P Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors Bioorg Med Chem Lett 5:2123-2128 (1995)    Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Enzyme
Mol. Mass.:
68692.62
Organism:
Human
Description:
P23219
Residue:
599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
  
Inhibitor
Name:
BDBM50285205
Synonyms:
3-(4-Ethanesulfonyl-phenyl)-2-(4-fluoro-phenyl)-thiophene | CHEMBL416687
Type:
Small organic molecule
Emp. Form.:
C18H15FO2S2
Mol. Mass.:
346.439
SMILES:
CCS(=O)(=O)c1ccc(cc1)-c1ccsc1-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: