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Target
Neutrophil elastase
Ligand
BDBM50286677
Substrate
n/a
Meas. Tech.
ChEBML_64293
KON
8800 M-1s-1
Citation
 Alpegiani, M; Bissolino, P; Corigli, R; Rizzo, V; Perrone, E Tricyclic cephems as inhibitors of human leukocyte elastase. Furo[3,4-c]cepham sulfones Bioorg Med Chem Lett 5:687-690 (1995)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50286677
Synonyms:
7-tert-Butyl-2-methoxy-4-(2,2-diphenyl-cyclopropyl)-3,3-dioxo-2,2a,3,4-tetrahydro-6-oxa-3lambda*6*-thia-7b-aza-cyclobuta[e]inden-1-one | CHEMBL161586
Type:
Small organic molecule
Emp. Form.:
C27H27NO5S
Mol. Mass.:
477.572
SMILES:
CO[C@@H]1[C@@H]2N(C1=O)c1c(coc1C(C)(C)C)[C@]1(CC1(c1ccccc1)c1ccccc1)S2(=O)=O
Structure:
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