Reaction Details Report a problem with these data
Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50293586
Substrate
n/a
Meas. Tech.
ChEMBL_571203 (CHEMBL1031962)
IC50
48000±n/a nM
Citation
 Heng, S; Gryncel, KR; Kantrowitz, ER A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorg Med Chem 17:3916-22 (2009) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_PIG | FBP | FBP1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36781.07
Organism:
Sus scrofa (Pig)
Description:
Liver FBPase (P00636)
Residue:
338
Sequence:
MTDQAAFDTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK
  
Inhibitor
Name:
BDBM50293586
Synonyms:
4-(2-(3-Nitrophenylamino)thiazol-4-yl)phenol | CHEMBL559762
Type:
Small organic molecule
Emp. Form.:
C15H11N3O3S
Mol. Mass.:
313.331
SMILES:
Oc1ccc(cc1)-c1csc(Nc2cccc(c2)[N+]([O-])=O)n1
Structure:
Search PDB for entries with ligand similarity: