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Target
Glycogen phosphorylase, muscle form
Ligand
BDBM50295848
Substrate
n/a
Meas. Tech.
ChEMBL_578476 (CHEMBL1063135)
IC50
350000±n/a nM
Citation
 Tóth, M; Kun, S; Bokor, E; Benltifa, M; Tallec, G; Vidal, S; Docsa, T; Gergely, P; Somsák, L; Praly, JP Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase. Bioorg Med Chem 17:4773-85 (2009) [PubMed]  Article 
Target
Name:
Glycogen phosphorylase, muscle form
Synonyms:
Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT
Type:
Enzyme
Mol. Mass.:
97296.32
Organism:
Oryctolagus cuniculus (rabbit)
Description:
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Residue:
843
Sequence:
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKIP
  
Inhibitor
Name:
BDBM50295848
Synonyms:
(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(5-p-tolyl-1,2,4-oxadiazol-3-yl)tetrahydro-2H-pyran-3,4,5-triol | CHEMBL559671
Type:
Small organic molecule
Emp. Form.:
C15H18N2O6
Mol. Mass.:
322.3132
SMILES:
Cc1ccc(cc1)-c1nc(no1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Structure:
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