Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50300159
Substrate
n/a
Meas. Tech.
ChEMBL_594167 (CHEMBL1039597)
Ki
43.6±n/a nM
Citation
 Frecentese, F; Fiorino, F; Perissutti, E; Severino, B; Magli, E; Esposito, A; De Angelis, F; Massarelli, P; Nencini, C; Viti, B; Santagada, V; Caliendo, G Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands. Eur J Med Chem 45:752-9 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT2C | 5-hydroxytryptamine receptor 2C | 5-hydroxytryptamine receptor 2C (5HT2c) | 5HT2C_RAT | 5ht1c | Htr1c | Htr2c | Serotonin (5-HT) receptor | Serotonin receptor 2a and 2c (5HT2A and 5HT2C)
Type:
Enzyme
Mol. Mass.:
51935.10
Organism:
Rat
Description:
P08909
Residue:
460
Sequence:
MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
  
Inhibitor
Name:
BDBM50300159
Synonyms:
CHEMBL583422 | Ethyl 5-(3-(4-((benzo[d][1,3]dioxol-5-yl)methyl)piperazin-1-yl)propoxy)-1H-indole-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C26H31N3O5
Mol. Mass.:
465.5414
SMILES:
CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5OCOc5c4)CC3)ccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: