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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM50300549
Substrate
n/a
Meas. Tech.
ChEMBL_588743 (CHEMBL1053690)
IC50
63000±n/a nM
Citation
 Beausoleil, E; Chauvignac, C; Taverne, T; Lacombe, S; Pognante, L; Leblond, B; Pallares, D; Oliveira, CD; Bachelot, F; Carton, R; Peillon, H; Coutadeur, S; Picard, V; Lambeng, N; Désiré, L; Schweighoffer, F Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. Bioorg Med Chem Lett 19:5594-8 (2009) [PubMed]  Article 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1 | RAC1_HUMAN | Ras-related C3 botulinum toxin substrate 1 | Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 | TC25
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1337921
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM50300549
Synonyms:
2,3-Dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium chloride | CHEMBL575979
Type:
Small organic molecule
Emp. Form.:
C19H18NO4
Mol. Mass.:
324.35
SMILES:
COc1ccc2cc3-c4cc(O)c(O)cc4CC[n+]3cc2c1OC
Structure:
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