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Target
Casein kinase I isoform delta
Ligand
BDBM50300891
Substrate
n/a
Meas. Tech.
ChEMBL_599899 (CHEMBL1045464)
IC50
340±n/a nM
Citation
 Peifer, C; Abadleh, M; Bischof, J; Hauser, D; Schattel, V; Hirner, H; Knippschild, U; Laufer, S 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem 52:7618-30 (2009) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CK1, delta | Casein kinase 1 Delta | Casein kinase I delta | Casein kinase I isoform delta | Csnk1d | Hckid | KC1D_RAT | casein kinase 1, delta
Type:
Enzyme
Mol. Mass.:
47342.73
Organism:
Rat
Description:
Q06486
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50300891
Synonyms:
(rac)-N-(4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)pyridin-2-yl)-2-phenoxypropanamide | CHEMBL566058
Type:
Small organic molecule
Emp. Form.:
C26H24FN3O3
Mol. Mass.:
445.4855
SMILES:
CC(C)c1onc(c1-c1ccnc(NC(=O)C(C)Oc2ccccc2)c1)-c1ccc(F)cc1
Structure:
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