Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50301643
Substrate
n/a
Meas. Tech.
ChEMBL_600730 (CHEMBL1037442)
IC50
0.64±n/a nM
Citation
 Takahashi, H; Haga, Y; Shibata, T; Nonoshita, K; Sakamoto, T; Moriya, M; Ohe, T; Chiba, M; Mitobe, Y; Kitazawa, H; Iwaasa, H; Ishihara, A; Ishii, Y; Kanatani, A; Fukami, T Identification of positron emission tomography ligands for NPY Y5 receptors in the brain. Bioorg Med Chem Lett 19:5436-9 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50301643
Synonyms:
CHEMBL570633 | trans-3'-oxo-N-(5-phenylpyrimidin-2-yl)-3'H-spiro[cyclohexane-1,1'-isobenzofuran]-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C24H21N3O3
Mol. Mass.:
399.4418
SMILES:
O=C(Nc1ncc(cn1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.23,wD:15.16,(-7.28,6.74,;-5.95,5.97,;-4.61,6.74,;-3.28,5.97,;-3.29,4.43,;-1.96,3.66,;-.62,4.43,;-.62,5.98,;-1.96,6.74,;.71,3.66,;.71,2.12,;2.05,1.35,;3.38,2.13,;3.37,3.67,;2.04,4.43,;-5.95,4.43,;-7.28,3.65,;-7.28,2.11,;-5.95,1.35,;-4.62,2.11,;-4.62,3.65,;-5.03,.1,;-5.93,-1.16,;-5.45,-2.62,;-7.41,-.69,;-8.75,-1.46,;-10.08,-.69,;-10.08,.86,;-8.75,1.63,;-7.42,.86,)|
Structure:
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