Reaction Details Report a problem with these data
Target
Prostaglandin E synthase
Ligand
BDBM31132
Substrate
n/a
Meas. Tech.
ChEMBL_604678 (CHEMBL1068501)
IC50
9200±n/a nM
Citation
Koeberle, A; Haberl, EM; Rossi, A; Pergola, C; Dehm, F; Northoff, H; Troschuetz, R; Sautebin, L; Werz, O Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1. Bioorg Med Chem 17:7924-32 (2009) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL