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Target
Monoglyceride lipase
Ligand
BDBM50307796
Substrate
n/a
Meas. Tech.
ChEMBL_612372 (CHEMBL1065624)
IC50
18000±n/a nM
Citation
 Onnis, V; Congiu, C; Björklund, E; Hempel, F; Söderström, E; Fowler, CJ Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors. J Med Chem 53:2286-98 (2010) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50307796
Synonyms:
4-Acetamidophenyl 2-(2-(4-(2-(trifluoromethyl)pyridin-4-ylamino)phenyl) | CHEMBL591932
Type:
Small organic molecule
Emp. Form.:
C25H23F3N4O4
Mol. Mass.:
500.4697
SMILES:
CC(C(=O)NCC(=O)Oc1ccc(NC(C)=O)cc1)c1ccc(Nc2ccnc(c2)C(F)(F)F)cc1
Structure:
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