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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50310075
Substrate
n/a
Meas. Tech.
ChEMBL_612206 (CHEMBL1074144)
Ki
13.7±n/a nM
Citation
 Rossi, D; Urbano, M; Pedrali, A; Serra, M; Zampieri, D; Mamolo, MG; Laggner, C; Zanette, C; Florio, C; Schepmann, D; Wuensch, B; Azzolina, O; Collina, S Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2). Bioorg Med Chem 18:1204-12 (2010) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50310075
Synonyms:
(E)-N-Benzyl-3-(6-methoxynaphthalen-2-yl)-N-methylbut-2-en-1-amine | CHEMBL597022
Type:
Small organic molecule
Emp. Form.:
C23H25NO
Mol. Mass.:
331.4507
SMILES:
COc1ccc2cc(ccc2c1)C(\C)=C\CN(C)Cc1ccccc1
Structure:
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