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Target
Tyrosine-protein kinase HCK
Ligand
BDBM50311925
Substrate
n/a
Meas. Tech.
ChEMBL_619934 (CHEMBL1113976)
IC50
11±n/a nM
Citation
 Zhang, G; Ren, P; Gray, NS; Sim, T; Wang, X; Liu, Y; Che, J; Dong, W; Tian, SS; Sandberg, ML; Spalding, TA; Romeo, R; Iskandar, M; Wang, Z; Seidel, HM; Karanewsky, DS; He, Y Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II. Bioorg Med Chem Lett 19:6691-5 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase HCK
Synonyms:
HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59600.18
Organism:
Homo sapiens (Human)
Description:
P08631
Residue:
526
Sequence:
MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
  
Inhibitor
Name:
BDBM50311925
Synonyms:
CHEMBL1075628 | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-1-tert-butyl-5-((4-methylpiperazin-1-yl)methyl)-1H-pyrazole-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C32H39N11O
Mol. Mass.:
593.7252
SMILES:
CN1CCN(Cc2cc(nn2C(C)(C)C)C(=O)Nc2ccc(C)c(Nc3nc4ccccc4n3-c3cc(N)ncn3)c2)CC1
Structure:
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