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Target
Thymidine kinase 2, mitochondrial
Ligand
BDBM50314837
Substrate
n/a
Meas. Tech.
ChEMBL_627482 (CHEMBL1111768)
IC50
300±n/a nM
Citation
Van Poecke, S; Negri, A; Gago, F; Van Daele, I; Solaroli, N; Karlsson, A; Balzarini, J; Van Calenbergh, S 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem 53:2902-12 (2010) [PubMed] Article
More Info.:
Target
Name:
Thymidine kinase 2, mitochondrial
Synonyms:
KITM_HUMAN | TK2 | Thymidine kinase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31013.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333885
Residue:
265
Sequence:
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
Inhibitor
Name:
BDBM50314837
Synonyms:
3'-(4-Benzyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | 3'-(4-Benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | CHEMBL1090133
Type:
Small organic molecule
Emp. Form.:
C19H21N5O4
Mol. Mass.:
383.4011
SMILES:
Cc1cn([C@H]2C[C@@H]([C@@H](CO)O2)n2cc(Cc3ccccc3)nn2)c(=O)[nH]c1=O |r|