Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM19427
Substrate
n/a
Meas. Tech.
ChEMBL_638011 (CHEMBL1166732)
IC50
>20000±n/a nM
Citation
 Bertrand, P Inside HDAC with HDAC inhibitors. Eur J Med Chem 45:2095-116 (2010) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM19427
Synonyms:
N-[2-amino-5-(thiophen-2-yl)phenyl]-4-methoxybenzamide | benzamide-type inhibitor, 23
Type:
Small organic molecule
Emp. Form.:
C18H16N2O2S
Mol. Mass.:
324.397
SMILES:
COc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: