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Target
Polycystin-2
Ligand
BDBM50324327
Substrate
n/a
Meas. Tech.
ChEMBL_650175 (CHEMBL1219873)
IC50
7±n/a nM
Citation
 Meredith, EL; Beattie, K; Burgis, R; Capparelli, M; Chapo, J; Dipietro, L; Gamber, G; Enyedy, I; Hood, DB; Hosagrahara, V; Jewell, C; Koch, KA; Lee, W; Lemon, DD; McKinsey, TA; Miranda, K; Pagratis, N; Phan, D; Plato, C; Rao, C; Rozhitskaya, O; Soldermann, N; Springer, C; van Eis, M; Vega, RB; Yan, W; Zhu, Q; Monovich, LG Identification of potent and selective amidobipyridyl inhibitors of protein kinase D. J Med Chem 53:5422-38 (2010) [PubMed]  Article 
Target
Name:
Polycystin-2
Synonyms:
PKD2 | PKD2_HUMAN | TRPP2
Type:
PROTEIN
Mol. Mass.:
109676.85
Organism:
Homo sapiens (Human)
Description:
ChEMBL_886731
Residue:
968
Sequence:
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGSSNVHV
  
Inhibitor
Name:
BDBM50324327
Synonyms:
2'-(1-Methyl-1H-pyrazol-3-ylamino)-6-piperazin-1-yl[2,4']bipyridinyl-4-carboxylic Acid Amide | CHEMBL1215074
Type:
Small organic molecule
Emp. Form.:
C19H22N8O
Mol. Mass.:
378.431
SMILES:
Cn1ccc(Nc2cc(ccn2)-c2cc(cc(n2)N2CCNCC2)C(N)=O)n1
Structure:
Search PDB for entries with ligand similarity: