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Target
Thymidylate synthase
Ligand
BDBM50326711
Substrate
n/a
Meas. Tech.
ChEMBL_661532 (CHEMBL1253096)
Ki
2700±n/a nM
Citation
 Garg, D; Henrich, S; Salo-Ahen, OM; Myllykallio, H; Costi, MP; Wade, RC Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs. J Med Chem 53:6539-49 (2010) [PubMed]  Article 
Target
Name:
Thymidylate synthase
Synonyms:
TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase
Type:
Enzyme
Mol. Mass.:
35718.07
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
313
Sequence:
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
  
Inhibitor
Name:
BDBM50326711
Synonyms:
1,3-propanediphosphonic acid | CHEMBL1230579 | PROPANE-1,3-DIYLBIS(PHOSPHONIC ACID)
Type:
Small organic molecule
Emp. Form.:
C3H10O6P2
Mol. Mass.:
204.0554
SMILES:
OP(O)(=O)CCCP(O)(O)=O
Structure:
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