Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50333493
Substrate
n/a
Meas. Tech.
ChEMBL_699228 (CHEMBL1646950)
Ki
>22000±n/a nM
Citation
 Simard, D; Leblanc, Y; Berthelette, C; Zaghdane, MH; Molinaro, C; Wang, Z; Gallant, M; Lau, S; Thao, T; Hamel, M; Stocco, R; Sawyer, N; Sillaots, S; Gervais, F; Houle, R; Lévesque, JF Azaindoles as potent CRTH2 receptor antagonists. Bioorg Med Chem Lett 21:841-5 (2011) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50333493
Synonyms:
(R)-2-(8-(4-fluoro-N-methylphenylsulfonamido)-6,7,8,9-tetrahydropyrido[4,3-b]indolizin-5-yl)acetic acid | CHEMBL1641807
Type:
Small organic molecule
Emp. Form.:
C20H20FN3O4S
Mol. Mass.:
417.454
SMILES:
CN([C@@H]1CCc2c(CC(O)=O)c3ccncc3n2C1)S(=O)(=O)c1ccc(F)cc1 |r|
Structure:
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