Reaction Details Report a problem with these data
Target
Glucocorticoid receptor
Ligand
BDBM50336935
Substrate
n/a
Meas. Tech.
ChEMBL_718595 (CHEMBL1680621)
Ki
927±n/a nM
Citation
 Richardson, TI; Clarke, CA; Yu, KL; Yee, YK; Bleisch, TJ; Lopez, JE; Jones, SA; Hughes, NE; Muehl, BS; Lugar, CW; Moore, TL; Shetler, PK; Zink, RW; Osborne, JJ; Montrose-Rafizadeh, C; Patel, N; Geiser, AG; Galvin, RJ Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids ACS Med Chem Lett 2:148-153 (2011) [PubMed]  Article 
Target
Name:
Glucocorticoid receptor
Synonyms:
GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Type:
Enzyme
Mol. Mass.:
85656.87
Organism:
Human
Description:
P04150
Residue:
777
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
  
Inhibitor
Name:
BDBM50336935
Synonyms:
CHEMBL1672544 | N-(3-(4-cyanophenyl)-1-ethyl-1H-indol-6-yl)methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C18H17N3O2S
Mol. Mass.:
339.411
SMILES:
CCn1cc(-c2ccc(cc2)C#N)c2ccc(NS(C)(=O)=O)cc12
Structure:
Search PDB for entries with ligand similarity: