Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 3
Ligand
BDBM50337261
Substrate
n/a
Meas. Tech.
ChEMBL_726362 (CHEMBL1687494)
IC50
63±n/a nM
Citation
 Shao, Y; Anilkumar, GN; Carroll, CD; Dong, G; Hall, JW; Hobbs, DW; Jiang, Y; Jenh, CH; Kim, SH; Kozlowski, JA; McGuinness, BF; Rosenblum, SB; Schulman, I; Shih, NY; Shu, Y; Wong, MK; Yu, W; Zawacki, LG; Zeng, Q II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists. Bioorg Med Chem Lett 21:1527-31 (2011) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
  
Inhibitor
Name:
BDBM50337261
Synonyms:
(S)-5-chloro-N-methyl-6-(3-methyl-4-(1-(trifluoromethyl)piperidin-4-yl)piperazin-1-yl)nicotinamide | CHEMBL1681834
Type:
Small organic molecule
Emp. Form.:
C18H25ClF3N5O
Mol. Mass.:
419.872
SMILES:
CNC(=O)c1cnc(N2CCN([C@@H](C)C2)C2CCN(CC2)C(F)(F)F)c(Cl)c1 |r|
Structure:
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