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Target
Beta-3 adrenergic receptor
Ligand
BDBM50338814
Substrate
n/a
Meas. Tech.
ChEMBL_727078 (CHEMBL1687002)
EC50
11±n/a nM
Citation
 Morriello, GJ; Wendt, HR; Bansal, A; Di Salvo, J; Feighner, S; He, J; Hurley, AL; Hreniuk, DL; Salituro, GM; Reddy, MV; Galloway, SM; McGettigan, KK; Laws, G; McKnight, C; Doss, GA; Tsou, NN; Black, RM; Morris, J; Ball, RG; Sanfiz, AT; Streckfuss, E; Struthers, M; Edmondson, SD Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective humanß3 adrenergic receptor agonists. Bioorg Med Chem Lett 21:1865-70 (2011) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50338814
Synonyms:
(R)-N-(4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenyl)-4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzenesulfonamide | CHEMBL1684578
Type:
Small organic molecule
Emp. Form.:
C32H28F3N3O3S2
Mol. Mass.:
623.708
SMILES:
O[C@@H](CNCCc1ccc(NS(=O)(=O)c2ccc(cc2)-c2nc(cs2)-c2ccc(cc2)C(F)(F)F)cc1)c1ccccc1 |r|
Structure:
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