Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM50341707
Substrate
n/a
Meas. Tech.
ChEMBL_743334 (CHEMBL1767581)
Ki
>100000±n/a nM
Citation
 Baragaña, B; McCarthy, O; Sánchez, P; Bosch-Navarrete, C; Kaiser, M; Brun, R; Whittingham, JL; Roberts, SM; Zhou, XX; Wilson, KS; Johansson, NG; González-Pacanowska, D; Gilbert, IH β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorg Med Chem 19:2378-91 (2011) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM50341707
Synonyms:
CHEMBL1766650 | rac-benzyl 4-(4-(tert-butyldiphenylsilyloxy)-2-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)butanoyl)piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C37H44N4O6Si
Mol. Mass.:
668.854
SMILES:
CC(C)(C)[Si](OCCC(Cn1ccc(=O)[nH]c1=O)C(=O)N1CCN(CC1)C(=O)OCc1ccccc1)(c1ccccc1)c1ccccc1
Structure:
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