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Target
Mannose-6-phosphate isomerase
Ligand
BDBM44461
Substrate
n/a
Meas. Tech.
ChEMBL_747525 (CHEMBL1777059)
IC50
1000±n/a nM
Citation
Dahl, R; Bravo, Y; Sharma, V; Ichikawa, M; Dhanya, RP; Hedrick, M; Brown, B; Rascon, J; Vicchiarelli, M; Mangravita-Novo, A; Yang, L; Stonich, D; Su, Y; Smith, LH; Sergienko, E; Freeze, HH; Cosford, ND Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem 54:3661-8 (2011) [PubMed] Article
More Info.:
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Human
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
Inhibitor
Name:
BDBM44461
Synonyms:
5-[(2-methoxyphenyl)-oxomethoxy]-1-phenyl-3-pyrazolecarboxylic acid ethyl ester | 5-o-anisoyloxy-1-phenyl-pyrazole-3-carboxylic acid ethyl ester | MLS000538601 | SMR000144638 | cid_1256813 | ethyl 5-(2-methoxybenzoyl)oxy-1-phenylpyrazole-3-carboxylate | ethyl 5-(2-methoxyphenyl)carbonyloxy-1-phenyl-pyrazole-3-carboxylate | ethyl 5-[(2-methoxybenzoyl)oxy]-1-phenyl-1H-pyrazole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H18N2O5
Mol. Mass.:
366.3673
SMILES:
CCOC(=O)c1cc(OC(=O)c2ccccc2OC)n(n1)-c1ccccc1