Reaction Details Report a problem with these data
Target
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Ligand
BDBM50345796
Substrate
n/a
Meas. Tech.
ChEMBL_749305 (CHEMBL1785240)
IC50
>300000±n/a nM
Citation
 Pereira, JM; Severino, RP; Vieira, PC; Fernandes, JB; da Silva, MF; Zottis, A; Andricopulo, AD; Oliva, G; Corrêa, AG Anacardic acid derivatives as inhibitors of glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi. Bioorg Med Chem 16:8889-95 (2008) [PubMed]  Article 
Target
Name:
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
Synonyms:
G3PG_TRYCR
Type:
PROTEIN
Mol. Mass.:
39070.68
Organism:
Trypanosoma cruzi
Description:
ChEMBL_973242
Residue:
359
Sequence:
MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMNTDAEYFAYQMRYDTVHGKFKYEVTTTKSSPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAAEGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHVVSNASCTTNCLAPIVHVLVKEGFGVQTGLMTTIHSYTATQKTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQGKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRASKTYMKGILGYTDEELVSADFINDNRSSIYDSKATLQNNLPKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL
  
Inhibitor
Name:
BDBM50345796
Synonyms:
CHEMBL1785008 | E/Z-ethyl 2-methoxy-6-(8-(tetrahydro-2H-pyran-2-yloxy)oct-1-enyl)benzoate
Type:
Small organic molecule
Emp. Form.:
C23H34O5
Mol. Mass.:
390.5131
SMILES:
CCOC(=O)c1c(OC)cccc1C=CCCCCCCOC1CCCCO1 |w:14.15|
Structure:
Search PDB for entries with ligand similarity: