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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50346176
Substrate
n/a
Meas. Tech.
ChEMBL_750693 (CHEMBL1785675)
Ki
69±n/a nM
Citation
 Breining, SR; Bencherif, M; Grady, SR; Whiteaker, P; Marks, MJ; Wageman, CR; Lester, HA; Yohannes, D Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype. Bioorg Med Chem Lett 19:4359-63 (2009) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_MOUSE | Acra7 | Chrna7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal nicotinic acetylcholine receptor
Type:
PROTEIN
Mol. Mass.:
56632.61
Organism:
Mus musculus
Description:
ChEMBL_144033
Residue:
502
Sequence:
MCGRRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGTHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50346176
Synonyms:
2-(pyridin-3-yl)quinuclidine dihydrochloride | CHEMBL1783885
Type:
Small organic molecule
Emp. Form.:
C12H16N2
Mol. Mass.:
188.2688
SMILES:
C1CN2CCC1CC2c1cccnc1 |(-1.29,-30.86,;-1.3,-32.41,;-2.64,-33.17,;-2.24,-31.8,;-3.17,-31.34,;-2.63,-30.09,;-3.97,-30.85,;-3.97,-32.4,;-5.31,-33.16,;-6.63,-32.39,;-7.97,-33.16,;-7.97,-34.7,;-6.63,-35.47,;-5.31,-34.7,)|
Structure:
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