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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50346179
Substrate
n/a
Meas. Tech.
ChEMBL_750693 (CHEMBL1785675)
Ki
9100±n/a nM
Citation
 Breining, SR; Bencherif, M; Grady, SR; Whiteaker, P; Marks, MJ; Wageman, CR; Lester, HA; Yohannes, D Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype. Bioorg Med Chem Lett 19:4359-63 (2009) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_MOUSE | Acra7 | Chrna7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal nicotinic acetylcholine receptor
Type:
PROTEIN
Mol. Mass.:
56632.61
Organism:
Mus musculus
Description:
ChEMBL_144033
Residue:
502
Sequence:
MCGRRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGTHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50346179
Synonyms:
8-methyl-3-(pyrimidin-5-yl)-8-azabicyclo[3.2.1]oct-2-ene bis(2,2,2-trifluoroacetate) | CHEMBL1783888
Type:
Small organic molecule
Emp. Form.:
C12H15N3
Mol. Mass.:
201.2676
SMILES:
CN1C2CCC1C=C(C2)c1cncnc1 |c:7|
Structure:
Search PDB for entries with ligand similarity: