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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50336579
Substrate
n/a
Meas. Tech.
ChEMBL_765261 (CHEMBL1827900)
Ki
304±n/a nM
Citation
 Zhang, Z; Yang, H; Wu, G; Li, Z; Song, T; Li, XQ Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design. Eur J Med Chem 46:3909-16 (2011) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50336579
Synonyms:
3-(4-methoxyphenoxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile | CHEMBL1672070
Type:
Small organic molecule
Emp. Form.:
C22H12N2O3
Mol. Mass.:
352.3423
SMILES:
COc1ccc(Oc2ccc3c4c(C#N)c(=O)nc4c4cccc2c34)cc1
Structure:
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