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Target
Bcl-2-like protein 1
Ligand
BDBM50352169
Substrate
n/a
Meas. Tech.
ChEMBL_767332 (CHEMBL1825444)
IC50
9370±n/a nM
Citation
 Rega, MF; Wu, B; Wei, J; Zhang, Z; Cellitti, JF; Pellecchia, M SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1. J Med Chem 54:6000-13 (2011) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50352169
Synonyms:
CHEMBL1824803
Type:
Small organic molecule
Emp. Form.:
C26H20FNO4S
Mol. Mass.:
461.505
SMILES:
Fc1ccc(cc1)-c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(COc2ccccc2)cc1
Structure:
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