Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM50240041
Substrate
n/a
Meas. Tech.
ChEMBL_776076 (CHEMBL1912772)
IC50
1500±n/a nM
Citation
 Thanigaimalai, P; Lee, KC; Sharma, VK; Joo, C; Cho, WJ; Roh, E; Kim, Y; Jung, SH Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase. Bioorg Med Chem Lett 21:6824-8 (2011) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50240041
Synonyms:
1-phenyl-2-thiourea | 1-phenylthiourea | CHEMBL263376 | N-Phenyl-thiourea | N-Phenylthiourea | phenylthiourea
Type:
Small organic molecule
Emp. Form.:
C7H8N2S
Mol. Mass.:
152.217
SMILES:
NC(=S)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: