Reaction Details Report a problem with these data
Target
Calcitonin gene-related peptide 1
Ligand
BDBM50224431
Substrate
n/a
Meas. Tech.
ChEMBL_775100 (CHEMBL1912359)
Ki
1200±n/a nM
Citation
 Zartman, CB; Bell, IM; Gallicchio, SN; Graham, SL; Kane, SA; Mallee, JJ; Rutledge, RZ; Salvatore, CA; Vacca, JP; Williams, TM Identification of a novel RAMP-independent CGRP receptor antagonist. Bioorg Med Chem Lett 21:6705-8 (2011) [PubMed]  Article 
Target
Name:
Calcitonin gene-related peptide 1
Synonyms:
CALCA_RAT | CGRP | Calc | Calca | Calcitonin gene-related peptide 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13950.43
Organism:
RAT
Description:
CGRP 0 RAT::P01256
Residue:
128
Sequence:
MGFLKFSPFLVVSILLLYQACGLQAVPLRSTLESSPGMAATLSEEEARLLLAALVQNYMQMKVRELEQEQEAEGSSVTAQKRSCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAFGRRRRDLQA
  
Inhibitor
Name:
BDBM50224431
Synonyms:
CHEMBL236593 | MK-0974 | N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Telcagepant
Type:
Small organic molecule
Emp. Form.:
C26H27F5N6O3
Mol. Mass.:
566.523
SMILES:
Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)n3c4cccnc4[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F
Structure:
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