Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50334158
Substrate
n/a
Meas. Tech.
ChEMBL_787915 (CHEMBL1918797)
Ki
0.59±n/a nM
Citation
 Moussa, IABanister, SDGiboureau, NMeikle, SRKassiou, M Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N'-[4-(2-fluoroethoxy)benzyl]piperazine, a novels1 receptor PET imaging agent. Bioorg Med Chem Lett 21:6820-3 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50334158
Synonyms:
1'-benzyl-3-(2-fluoroethyl)-3H-spiro[[2]benzofuran-1,4'-piperidine | CHEMBL1645202 | CHEMBL2314421
Type:
Small organic molecule
Emp. Form.:
C21H24FNO
Mol. Mass.:
325.4198
SMILES:
FCCC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Structure:
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