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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50357888
Substrate
n/a
Meas. Tech.
ChEMBL_787640 (CHEMBL1918093)
IC50
195±n/a nM
Citation
 Lumeras, W; Vidal, L; Vidal, B; Balagué, C; Orellana, A; Maldonado, M; Domínguez, M; Segarra, V; Caturla, F 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem 54:7899-910 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50357888
Synonyms:
CHEMBL1916345
Type:
Small organic molecule
Emp. Form.:
C20H11ClF2N2O
Mol. Mass.:
368.764
SMILES:
[O-][n+]1ccc2c(ccnc2c1-c1ccccc1Cl)-c1ccc(F)cc1F |(3.33,-20.74,;4.66,-19.97,;4.66,-18.43,;5.99,-17.65,;7.33,-18.42,;8.66,-17.64,;10,-18.42,;10,-19.97,;8.66,-20.74,;7.33,-19.97,;6,-20.74,;6,-22.27,;7.33,-23.04,;7.34,-24.57,;6,-25.35,;4.67,-24.58,;4.67,-23.05,;3.33,-22.28,;8.66,-16.11,;7.33,-15.35,;7.33,-13.81,;8.66,-13.03,;8.66,-11.49,;10,-13.8,;10,-15.34,;11.33,-16.11,)|
Structure:
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