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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50357890
Substrate
n/a
Meas. Tech.
ChEMBL_787640 (CHEMBL1918093)
IC50
148±n/a nM
Citation
 Lumeras, W; Vidal, L; Vidal, B; Balagué, C; Orellana, A; Maldonado, M; Domínguez, M; Segarra, V; Caturla, F 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem 54:7899-910 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50357890
Synonyms:
CHEMBL1916347
Type:
Small organic molecule
Emp. Form.:
C22H16F2N2O
Mol. Mass.:
362.372
SMILES:
Cc1cccc(C)c1-c1[n+]([O-])ccc2c(ccnc12)-c1ccc(F)cc1F |(25.95,-22.11,;27.28,-22.87,;27.29,-24.41,;28.62,-25.18,;29.96,-24.4,;29.95,-22.86,;31.28,-22.09,;28.62,-22.1,;28.61,-20.57,;27.28,-19.8,;25.95,-20.57,;27.28,-18.25,;28.61,-17.48,;29.95,-18.25,;31.28,-17.47,;32.62,-18.25,;32.62,-19.8,;31.27,-20.56,;29.94,-19.79,;31.28,-15.94,;29.95,-15.18,;29.94,-13.64,;31.28,-12.86,;31.28,-11.32,;32.62,-13.63,;32.62,-15.17,;33.95,-15.94,)|
Structure:
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